Rimsha Iqbal2025-09-102025-09-102025-07-05https://research.superior.edu.pk/handle/123456789/928Abstract Objective: The objective of this study was to determine the prevalence of anxiety and depression among dental professionals in Pakistan and to evaluate the demographic and occupational factors influencing these conditions. Methodology: A 12-month cross-sectional study was conducted across dental colleges, hospitals, and private practices in major urban cities of Pakistan. A total of 250 dental professionals were enrolled through stratified random sampling. Validated tools (HADS, PHQ-9) were used. Data were analyzed using SPSS v25, applying chi-square tests, ANOVA, and logistic regression. Results: The prevalence of anxiety was 42.4% and depression 36.8%. Female professionals and those with <5 years of experience exhibited significantly higher distress (p<0.05). Logistic regression showed female gender (OR=1.9, CI 1.2–3.0), <5 years’ experience (OR=2.1, CI 1.3–3.4), and workload >40 hours/week (OR=2.3, CI 1.4–3.8) as strong predictors. Conclusion: Anxiety and depression are highly prevalent among Pakistani dental professionals. Early-career practitioners, women, and those with heavy workloads are most at risk. Structured mental health programs and institutional interventions are recommended. Keywords: Dental professionals, anxiety, depression, prevalence, occupational stress, Pakistan, HADS, PHQ-9.