Comparing bleomycin and sodium tetradecyl sulfate for treatment of low flow craniomaxillofacial venous malformations
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Date
2025-03-01
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Abstract
Objective: To compare the efficacy of bleomycin
versus sodium tetradecyl sulfate for the treatment of low
flow craniomaxillofacial venous malformations in
the Pakistani population.
Methodology: This study utilized a randomized
controlled trial design and was conducted at the
Department of Oral & Maxillofacial Surgery, Allama
Iqbal Medical College/Jinnah Hospital, Lahore, over six
months. Patients who underwent sclerotherapy were
given prophylactic antihistamine medication before the
procedure. Patients with abnormal values in specific
blood tests were excluded. Two groups were formed:
Group A received a combination of xylocaine with
adrenaline and bleomycin, while Group B received
sodium tetradecyl sulfate. Outcome was assessed in
both groups.
Results: The study enrolled participants with an age
range of 8 to 40 years. The duration of symptoms varied
from 8 to 24 months. The size of the lesions ranged from
6×10mm to 40×40mm. The study population consisted
of 43.2% male patients and 56.8% female patients.
Statistical analysis using the chi-square test revealed a
significant association between treatment efficacy and
the two groups, with a p-value of 0.020.
Conclusion: This study compares the efficacy of
Bleomycin and Sodium Tetradecyl Sulfate (STS) in
treating low-flow craniomaxillofacial venous
malformations, with Bleomycin demonstrating a higher
response rate, particularly in facial and oral cavity
lesions. The findings support sclerotherapy as an
effective minimally invasive treatment.